Nitric oxide: Synthesis, Pathophysiology and Application on Oncology and Cardiovascular Diseases

Mourad, Mai A. E.; Aly, Omar M.; Mourad, Ahmed A. E.

doi:10.21608/odr.2022.154048.1001

Nitric oxide: Synthesis, Pathophysiology and Application on Oncology and Cardiovascular Diseases

Document Type : Review Articles

Authors

¹ Associate professor of medicinal chemistry, Medicinal chemistry department, Faculty of pharmacy, Port Said university

² Department of Medicinal Chemistry, Faculty of Pharmacy, Port Said University

³ Pharmacology and Toxicology Department, Faculty of Pharmacy, Port-Said University, Port-Said, Egypt

10.21608/odr.2022.154048.1001

Abstract

Nitric oxide (NO), is a ubiquitous, water soluble, free radical gas, which plays key role in various physiological as well as pathological processes. Over past decades, NO has emerged as a molecule of interest in carcinogenesis and tumor growth progression. On the other hand, it is also emerging as a potential anti-oncogenic agent. Strategies for manipulating in vivo production and exogenous delivery of this molecule for therapeutic gain are being investigated. However, further validation and experimental/clinical trials are required for development of novel strategies based on NO for cancer treatment and prevention. On the other hand, NO mediates multiple physiological and pathophysiological processes in the cardiovascular system. Moreover, pharmacological compounds that release NO have been useful tools for evaluating the pivotal role of NO in cardiovascular physiology and therapeutics. This review discusses the range of actions of NO in cancer, various mechanisms by which NO acts in different cancers such as breast, cervical, gastric,colorectal, and head and neck cancers are addressed. It also offers an insight into the role of NO in managment of cardiovascular diseases.

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